Labyrinthitis secondary to experimental otitis media

Analysis of labyrinthitis in a model of otitis media. Morphologic study in 20 Wistar rats in which otitis media was induced by transbullar inoculation of Pseudomonas aeruginosa with obstruction of the eustachian tube. Seventy percent of rats showed vestibular signs. Histologic changes ranged from no...

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Bibliographic Details
Published in:American journal of otolaryngology 2005-07, Vol.26 (4), p.226-229
Main Authors: Trinidad, Almudena, Ramírez-Camacho, Rafael, García-Berrocal, Jose Ramon, Verdaguer, Jose María, Daza, Rosa
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Case-Control Studies
Disease Models, Animal
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Follow-Up Studies
Hearing Loss, Sensorineural - etiology
Labyrinthitis - etiology
Labyrinthitis - pathology
Male
Medical sciences
Non tumoral diseases
Otitis Media - complications
Otorhinolaryngology. Stomatology
Otoscopy
Rats
Rats, Wistar
Round Window, Ear - pathology
Vestibular Diseases - etiology
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Summary:Analysis of labyrinthitis in a model of otitis media. Morphologic study in 20 Wistar rats in which otitis media was induced by transbullar inoculation of Pseudomonas aeruginosa with obstruction of the eustachian tube. Seventy percent of rats showed vestibular signs. Histologic changes ranged from nonaffected labyrinths to suppurative labyrinthitis. Dissemination of infection probably occurs through round window membrane. A thinner round window membrane typical of rodents would be the reason for a more severe clinical and morphologic picture in rats when compared to human beings.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2005.01.003