The emerging role of CD44 in regulating skeletal micrometastasis

The hyaluronan (HA) receptor CD44 has a well documented role in tumour metastasis. This review focuses on the potential significance of CD44 expression and function in regulating the metastasis of both haematological malignancies and solid tumours to the bone. Specifically, the review will discuss t...

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Bibliographic Details
Published in:Cancer letters 2006-06, Vol.237 (1), p.1-9
Main Authors: Hill, Ashleigh, McFarlane, Suzanne, Johnston, Patrick G., Waugh, David J.J.
Format: Article
Language:English
Subjects:
Animals
Bone
Bone Marrow - immunology
Bone Marrow - metabolism
Bone Marrow - pathology
Bone Neoplasms - immunology
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
Bone Remodeling
Breast cancer
Cancer
Cathepsin K
CD44
Cell Adhesion - immunology
Cell Proliferation
Endothelial Cells - immunology
Endothelial Cells - metabolism
Endothelial Cells - pathology
Genes
Hematologic Neoplasms - immunology
Hematologic Neoplasms - metabolism
Hematologic Neoplasms - pathology
Humans
Hyaluronan
Hyaluronan Receptors - metabolism
Hyaluronic Acid - metabolism
Kinases
Medical research
Metastasis
MMP-9
Neoplastic Cells, Circulating - immunology
Neoplastic Cells, Circulating - metabolism
Neoplastic Cells, Circulating - pathology
Prostate cancer
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Summary:The hyaluronan (HA) receptor CD44 has a well documented role in tumour metastasis. This review focuses on the potential significance of CD44 expression and function in regulating the metastasis of both haematological malignancies and solid tumours to the bone. Specifically, the review will discuss the evidence that HA-CD44 interactions facilitate the arrest of circulating malignant cells upon the bone marrow endothelial cells and discuss data that suggests CD44 may orchestrate the ability of tumour cells to regulate the modification of the bone matrix and support its colonisation by malignant cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.05.006