Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections

Human metapneumovirus (hMPV) is a recently discovered pathogen in respiratory tract infection. The published literature suggests milder illness severity in hMPV compared with respiratory syncytial virus (RSV) infection. In two consecutive seasons, 637 nasopharyngeal aspirates from pediatric patients...

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Bibliographic Details
Published in:European journal of pediatrics 2006-07, Vol.165 (7), p.467-475
Main Authors: WILKESMANN, Anja, SCHILDGEN, Oliver, EIS-HIIBINGER, Anna Maria, GEIKOWSKI, Tilman, GLATZEL, Thomas, LENTZE, Michael J, BODE, Udo, SIMON, Arne
Format: Article
Language:English
Subjects:
Airway management
Biological and medical sciences
Chi-Square Distribution
Child, Preschool
Disease
Female
General aspects
Hospitalization
Hospitals
Humans
Illnesses
Infant
Infections
Male
Medical sciences
Metapneumovirus - isolation & purification
Metapneumovirus - pathogenicity
Neuromuscular diseases
Oxygen saturation
Paramyxoviridae Infections - diagnosis
Paramyxoviridae Infections - microbiology
Paramyxoviridae Infections - physiopathology
Pathogens
Pediatrics
Physicians
Pneumonia
Polymerase Chain Reaction
Premature birth
Pulse oximetry
Respiratory failure
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - physiopathology
Retrospective Studies
Risk Factors
Severity of Illness Index
Statistics, Nonparametric
Surveillance
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Summary:Human metapneumovirus (hMPV) is a recently discovered pathogen in respiratory tract infection. The published literature suggests milder illness severity in hMPV compared with respiratory syncytial virus (RSV) infection. In two consecutive seasons, 637 nasopharyngeal aspirates from pediatric patients were tested by hMPV polymerase chain reaction, and risk factors and clinical and laboratory items were analyzed. The hMPV patients were compared with hMPV-negative but RSV-positive patients by matched pair analysis. HMPV was detected in 17.9% of all samples. In total, 88 hMPV-infected patients with complete datasets were considered. More than half of all hMPV patients were older than 12 months, 45.5% had at least one risk factor for a severe course of viral respiratory tract infection, and 27.3% were born prematurely, 15.9% with a birth weight
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-006-0105-4