Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses

Cells activate complex signaling networks in response to DNA damage. Several proteins and protein complexes are involved in sensing DNA lesions and initiating the DNA damage response networks. The subsequent DNA damage responses, including the initiation of DNA repair pathways, the activation of cel...

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Bibliographic Details
Published in:Molecular carcinogenesis 2006-06, Vol.45 (6), p.403-408
Main Authors: Kim, Ja-Eun, Minter-Dykhouse, Katherine, Chen, Junjie
Format: Article
Language:English
Subjects:
Apoptosis
ATM
DNA Damage
DNA damage response
DNA-Binding Proteins - physiology
Humans
MDC1
MRN complex
Nuclear Proteins - physiology
Signal Transduction - physiology
Trans-Activators - physiology
γ-H2AX
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Summary:Cells activate complex signaling networks in response to DNA damage. Several proteins and protein complexes are involved in sensing DNA lesions and initiating the DNA damage response networks. The subsequent DNA damage responses, including the initiation of DNA repair pathways, the activation of cell cycle checkpoint controls and the induction of apoptosis, help maintain genomic stability in mammalian systems. Failure to establish the appropriate DNA damage signaling networks results in genomic instability, which is a known causal factor in tumorigenesis. This review will discuss recent progress in the understanding of the mechanisms by which mammalian cells sense DNA lesions and transduce DNA damage signals during early DNA damage responses. © 2006 Wiley‐Liss, Inc.
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.20221