Are endometrial polyps from pre-menopausal women similar to post-menopausal women? An immunohistochemical comparison of endometrial polyps from pre- and post-menopausal women

Do endometrial polyps from pre- and post-menopausal women have similar immunohistochemical expression of oestrogen and progesterone receptors (ER, PR) and markers of cellular proliferation/apoptosis (Ki67 and Bcl-2). Prospective cohort study. Non-parametric statistical analysis was used. Polyps recr...

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Bibliographic Details
Published in:Maturitas 2006-06, Vol.54 (3), p.277-284
Main Authors: McGurgan, P., Taylor, L.J., Duffy, S.R., O’Donovan, P.J.
Format: Article
Language:English
Subjects:
Adult
Bcl-2
Biological and medical sciences
Cohort Studies
Endometrial Neoplasms - metabolism
Endometrial polyps
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Ki67
Medical sciences
Middle Aged
Oestrogen receptor
Polyps - metabolism
Postmenopause
Premenopause
Progesterone receptor
Prospective Studies
Puberal and climacteric disorders (male and female)
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
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Summary:Do endometrial polyps from pre- and post-menopausal women have similar immunohistochemical expression of oestrogen and progesterone receptors (ER, PR) and markers of cellular proliferation/apoptosis (Ki67 and Bcl-2). Prospective cohort study. Non-parametric statistical analysis was used. Polyps recruited from women attending an out-patient hysteroscopy clinic in a UK district general hospital. Fourteen pre-menopausal and 16 post-menopausal women who presented with abnormal bleeding with endometrial polyps. Immunohistochemical staining was performed on endometrial polyps. Significant differences or correlations between hormone receptor expression (oestrogen and progesterone) and cell growth indices (Ki67 and Bcl-2). Endometrial polyps from pre- and post-menopausal women had significant differences in their expression of hormone receptors and Ki67. However, polyps from both groups of women had similarly increased levels of Bcl-2, an inhibitor of apoptosis. Pre- and post-menopausal polyps exhibit differing hormone receptor and proliferation markers, presumably a result of their hormonal milieu. However, both groups appear to have lost the usual control mechanisms for apoptotic regulation, this appears to be responsible for their growth.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2005.12.003