Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case

Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tum...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2006-06, Vol.36 (6), p.559-562
Main Authors: Higuchi, Ryota, Yamamoto, Masakazu, Hatori, Takashi, Shimizu, Koichi, Imai, Kenichirou, Takasaki, Ken
Format: Article
Language:English
Subjects:
Adenocarcinoma - surgery
Adenocarcinoma - therapy
Bile Duct Neoplasms - surgery
Bile Duct Neoplasms - therapy
Bile Ducts, Intrahepatic
CD3 Complex - immunology
Cholangiocarcinoma - surgery
Cholangiocarcinoma - therapy
Combined Modality Therapy
Dendritic Cells - immunology
Female
Humans
Immunotherapy - methods
Lymphatic Metastasis
Lymphocyte Activation
Middle Aged
T-Lymphocytes - immunology
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Summary:Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-006-3201-1