Cholesterol–bile salt vesicles as potential delivery vehicles for drug and vaccine delivery

The aim of this study was to further investigate the interactions between cholesterol (CH) and mixed bile salts (BS) (sodium cholate and sodium deoxycholate) and their suitability for drug and vaccine delivery. Insulin was used as a model protein to assess the ability of CH:BS vesicles to entrap a t...

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Bibliographic Details
Published in:International journal of pharmaceutics 2005-07, Vol.298 (2), p.339-343
Main Authors: Martin, C., Thongborisute, J., Takeuchi, H., Yamamoto, H., Kawashima, Y., Alpar, H.O.
Format: Article
Language:English
Subjects:
Bile Acids and Salts - chemistry
Bile salts
Biological and medical sciences
Cholesterol
Cholesterol - chemistry
Drug Delivery Systems
Electrochemistry
Fluorescein-5-isothiocyanate
General pharmacology
Insulin - administration & dosage
Insulin - chemistry
Medical sciences
Micelles
Microscopy, Atomic Force
Microscopy, Fluorescence
Pharmaceutical technology. Pharmaceutical industry
Pharmaceutical Vehicles
Pharmacology. Drug treatments
Vaccine delivery
Vaccines - administration & dosage
Vaccines - chemistry
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Summary:The aim of this study was to further investigate the interactions between cholesterol (CH) and mixed bile salts (BS) (sodium cholate and sodium deoxycholate) and their suitability for drug and vaccine delivery. Insulin was used as a model protein to assess the ability of CH:BS vesicles to entrap a therapeutically relevant macromolecule. The association of protein (FITC–insulin) with the CH:BS structure was confirmed with fluorescence microscopy, and the overall morphology of the vesicles was examined with atomic force microscopy (AFM). Results demonstrate that the nature of the vesicles formed between CH and BS is dependent not only on the concentration of BS but also on the increasing CH concentration leading to CH crystal formation.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2005.03.038