Hepatitis delta virus infection in chronically HBV-infected patients from northern Poland

The objective of this study was to estimate the presence of hepatitis delta virus RNA in chronically HBV-infected patients from northern Poland. Three out of 63 studied samples (4.8%) were positive in a qualitative test for total antibodies to HDV antigen. Five samples (7.9%) turned out to be HDV-RN...

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Bibliographic Details
Published in:Archives of virology 2006-06, Vol.151 (6), p.1207-1215
Main Authors: Bielawski, K P, Zietkowski, D, Charmuszko, U, Sikorska, K, Stalke, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acid Sequence
Antibodies
Antigens
Base Sequence
Biotechnology
Child
Enzymes
Female
Genomes
Genotype
Genotype & phenotype
Hepatitis Antibodies - blood
Hepatitis B
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - virology
Hepatitis D - complications
Hepatitis D - virology
Hepatitis D virus
Hepatitis delta virus
Hepatitis Delta Virus - classification
Hepatitis Delta Virus - genetics
Hepatitis Delta Virus - immunology
Humans
Infections
Infectious diseases
Male
Middle Aged
Molecular Sequence Data
Phylogenetics
Phylogeny
Poland
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
RNA, Viral - genetics
Sequence Analysis, DNA
Sequence Homology
Seroepidemiologic Studies
Serology
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Summary:The objective of this study was to estimate the presence of hepatitis delta virus RNA in chronically HBV-infected patients from northern Poland. Three out of 63 studied samples (4.8%) were positive in a qualitative test for total antibodies to HDV antigen. Five samples (7.9%) turned out to be HDV-RNA-positive by RT-PCR, four of them were sequenced in the region of L-HDAg, and phylogenetic analysis was performed. All four examined samples belonged to genotype I. Two RNA-positive/anti-HD-negative samples possessed a few uncommon nucleotide substitution sites within the L-HDAg sequence, which could suggest unique variants in the Polish population of HDV-infected patients.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-005-0700-0