Malignant transformation within a dermoid cyst: a case report and literature review

Malignant transformation within a dermoid cyst is a rare event. The most common transformation is to squamous cell carcinoma. Patients are often elderly and present with advanced disease. The prognosis tends to be very poor. We present a case of locally invasive squamous cell carcinoma arising from...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2006-06, Vol.274 (3), p.178-180
Main Authors: Sanghera, P, El Modir, A, Simon, J
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - pathology
Case reports
Cell Transformation, Neoplastic
Cysts
Dermoid Cyst - pathology
Fatal Outcome
Female
Humans
Middle Aged
Ovarian Neoplasms - pathology
Squamous cell carcinoma
Surgery
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Summary:Malignant transformation within a dermoid cyst is a rare event. The most common transformation is to squamous cell carcinoma. Patients are often elderly and present with advanced disease. The prognosis tends to be very poor. We present a case of locally invasive squamous cell carcinoma arising from a dermoid cyst in a 48-year-old lady. She underwent debulking surgery with no gross residual disease remaining. Within 2 months of the surgery she had recurrent disease and this was resistant to single agent carboplatin chemotherapy. She died 4 months after her initial surgery. We discuss the difficulties in diagnosing such tumours, the poor prognosis and review the various adjuvant treatment strategies that have been used in attempt to improve the outcome.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-006-0139-x