Classical Tone-Shock Conditioning Induces Zenk Expression in the Pigeon (Columba livia ) Hippocampus

The hippocampus is involved in fear conditioning, although the molecular events underlying this function are still under investigation. The authors analyzed the expression of the Zenk proto-oncogene product within the pigeon ( Columba livia ) hippocampus after training with a classical aversive cond...

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Bibliographic Details
Published in:Behavioral neuroscience 2006-04, Vol.120 (2), p.353-361
Main Authors: Brito, I, Britto, L. R. G, Ferrari, E. A. M
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Animal
Animal behavior
Animals
Aversion Conditioning
Behavior, Animal
Biological and medical sciences
Birds
Cell Count
Columba livia
Columbidae
Conditioned Fear
Conditioning
Conditioning, Classical - physiology
Early Growth Response Protein 1 - metabolism
Fear & phobias
Freezing Reaction, Cataleptic - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression
Gene Expression - physiology
Gene Expression - radiation effects
Genes
Hippocampus
Hippocampus - cytology
Hippocampus - metabolism
Immunohistochemistry - methods
Learning. Memory
Male
Neurons - metabolism
Pigeons
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Time Factors
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Summary:The hippocampus is involved in fear conditioning, although the molecular events underlying this function are still under investigation. The authors analyzed the expression of the Zenk proto-oncogene product within the pigeon ( Columba livia ) hippocampus after training with a classical aversive conditioning protocol using tone-shock associations. Control groups were trained with shock or tone alone or were only exposed to the experimental chamber and manipulated. Experimental pigeons showed significant increases of Zenk expression in the ventromedial region of the hippocampus, whereas both the experimental and shock groups had increased Zenk expression in the dorsal region. The expression of Zenk in specific neuronal populations within the pigeon hippocampus may be indicative of plasticity-associated aversive classical conditioning.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.120.2.353