A family study of early-onset obsessive-compulsive disorder

Results from family studies have suggested that obsessive‐compulsive disorder (OCD) is a genetically heterogeneous disorder and have emphasized the importance of identifying valid subgroups of patients. The current study focused on early‐onset OCD probands and examined the recurrence risks of OCD an...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2005-07, Vol.136B (1), p.92-97
Main Authors: do Rosario-Campos, Maria Conceição, Leckman, James F., Curi, Mariana, Quatrano, Susan, Katsovitch, Lylia, Miguel, Euripedes C., Pauls, David L.
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Child
childhood onset
Chronic Disease
comorbid tic disorders
Comorbidity
Family Health
family study
Female
genetics
Humans
Male
obsessive compulsive disorder
Obsessive-Compulsive Disorder - epidemiology
Obsessive-Compulsive Disorder - genetics
Obsessive-Compulsive Disorder - pathology
Odds Ratio
Risk Factors
Tic Disorders - epidemiology
Tic Disorders - genetics
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Summary:Results from family studies have suggested that obsessive‐compulsive disorder (OCD) is a genetically heterogeneous disorder and have emphasized the importance of identifying valid subgroups of patients. The current study focused on early‐onset OCD probands and examined the recurrence risks of OCD and tics among first‐degree family members. One hundred six children and adolescents with OCD were recruited from a specialty clinic for OCD and 44 control individuals without OCD were identified by random‐digit dialing. These 150 probands and their 465 first‐degree relatives were assessed by trained interviewers, using standardized semi‐structured interviews. Diagnoses were assigned according to DSM‐IV criteria by two experts blind to the proband's diagnosis, through the best‐estimate process. These data were analyzed using χ2 tests, t‐tests, logistic regression, and generalized estimating equations (GEE). Case probands had a mean age of onset of OC symptoms of 6.7 years (SD = 2.8), and high comorbid rates with Tourette syndrome (33%) and chronic tics (13.2%). Compared to control relatives, case relatives had higher age‐corrected recurrence risks of OCD (22.7% vs. 0.9%, odds ratio (OR) = 32.5, 95% confidence interval (CI) = 4.5–230.8, P = 0.0005), and chronic tics (11.6% vs. 1.7%, OR = 7.9, 95% CI = 1.9–33.1, P = 0.005). A comorbid diagnosis of tics in the relatives was the best predictor of their diagnosis of OCD (OR = 7.35, 95% CI = 3.79–14.25, P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30149