Short-term anti-plaque effect of two chlorhexidine varnishes

Background: Chlorhexidine (CHX) varnishes have been mainly used for the prevention of caries in high‐risk populations. Reports regarding their anti‐plaque effect on a clinical level are limited to non‐existing as opposed to their microbiological impact on plaque formation. Aim: The aim of this preli...

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Bibliographic Details
Published in:Journal of clinical periodontology 2005-08, Vol.32 (8), p.899-904
Main Authors: Cosyn, Jan, Wyn, Iris, De Rouck, Tim, Collys, Kris, Bottenberg, Peter, Matthijs, Stefan, Moradi Sabzevar, Mehran
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents, Local - therapeutic use
anti-plaque effect
automatic image analysis
Chlorhexidine - analogs & derivatives
Chlorhexidine - therapeutic use
chlorhexidine varnish
clinical study
Cross-Over Studies
Dental Plaque - drug therapy
Dental Plaque Index
Dentistry
Drug Combinations
Female
Humans
Male
Mouthwashes - therapeutic use
Photography, Dental
Single-Blind Method
Statistics, Nonparametric
Thymol - therapeutic use
Time Factors
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Summary:Background: Chlorhexidine (CHX) varnishes have been mainly used for the prevention of caries in high‐risk populations. Reports regarding their anti‐plaque effect on a clinical level are limited to non‐existing as opposed to their microbiological impact on plaque formation. Aim: The aim of this preliminary investigation was to evaluate the anti‐plaque effect of two CHX varnishes applied on sound enamel in relation to a positive control, a negative control and to one another. Methods: Sixteen healthy subjects volunteered for this randomized‐controlled, single‐blind, four‐treatment–four‐period crossover‐designed clinical trial. A 3‐day plaque re‐growth model was used to determine de novo plaque accumulation following CHX rinsing, Cervitec® application, EC40® application and no therapy. The amount of plaque was measured using the Quigley and Hein plaque index and “automatic image analysis” (AIA). Results and Conclusions: Varnish treatment resulted in significantly higher plaque levels than CHX rinsing irrespective of the varnish that was used (p0.002), implying that the latter is likely to remain the gold standard as an anti‐plaque agent. However, highly significant differences were also found in favour of both varnish systems when compared with no therapy (p
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.2005.00787.x