Cellular Signalling: STIMulating Calcium Entry

The molecular identity of the signal coupling intracellular Ca 2+ store depletion to the activation of Ca 2+ entry has long resisted exposure. Two recent studies independently implicate the STIM protein family as essential components in this coupling. These data provide new impetus to resolve how st...

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Bibliographic Details
Published in:Current biology 2005-07, Vol.15 (13), p.R493-R495
Main Author: Marchant, Jonathan S.
Format: Article
Language:English
Subjects:
Biological Transport, Active - physiology
Calcium - metabolism
Calcium Channels - metabolism
Endoplasmic Reticulum - metabolism
HeLa Cells
Humans
Ion Transport - physiology
Membrane Proteins - metabolism
Models, Biological
Neoplasm Proteins - metabolism
RNA Interference
Signal Transduction - physiology
Stromal Interaction Molecule 1
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Summary:The molecular identity of the signal coupling intracellular Ca 2+ store depletion to the activation of Ca 2+ entry has long resisted exposure. Two recent studies independently implicate the STIM protein family as essential components in this coupling. These data provide new impetus to resolve how store Ca 2+ content is sensed and communicated to store-operated Ca 2+ channels at the cell surface.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2005.06.035