Brain SPECT imaging in children and adolescents with obsessive-compulsive disorder

To evaluate the patterns of regional cerebral blood flow (rCBF) in cortical and subcortical regions by Brain SPECT imaging, in children and adolescents with obsessive-compulsive disorder (OCD) before and after treatment. Fourteen OCD patients (6 to 17 years old) underwent brain SPECT; ten of those s...

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Bibliographic Details
Published in:Journal of Neural Transmission 2005-08, Vol.112 (8), p.1115-1129
Main Authors: Castillo, A R G L, Buchpiguel, C A, de Araújo, L A S B, Castillo, J C R, Asbahr, F R, Maia, A K, de Oliveira Latorre, M R D
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Age of Onset
Brain Mapping
Cerebral Cortex - blood supply
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Cerebrovascular Circulation - physiology
Child
Female
Frontal Lobe - blood supply
Frontal Lobe - diagnostic imaging
Frontal Lobe - physiopathology
Functional Laterality - physiology
Humans
Male
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - drug therapy
Obsessive-Compulsive Disorder - physiopathology
Parietal Lobe - blood supply
Parietal Lobe - diagnostic imaging
Parietal Lobe - physiopathology
Predictive Value of Tests
Tomography, Emission-Computed, Single-Photon
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Summary:To evaluate the patterns of regional cerebral blood flow (rCBF) in cortical and subcortical regions by Brain SPECT imaging, in children and adolescents with obsessive-compulsive disorder (OCD) before and after treatment. Fourteen OCD patients (6 to 17 years old) underwent brain SPECT; ten of those subjects were reexamined after successful treatment. rCBF ratios were correlated with clinical parameters on the 14 patients in symptomatic state, and we compared rCBF ratios of the ten patients before and after treatment. There was no statistically significant difference in average ratios of rCBF before and after treatment. There were significant clinical correlations between current age and age of onset of OCD and rCBF in the bilateral superior frontal, and bilateral parietal cortical regions. Further investigations on abnormal neurodevelopment of cortical-subcortical circuits possibly involved in symptomatology of paediatric OCD are warranted.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-004-0240-x