Multidrug resistance among different serotypes of clinical Salmonella isolates in Taiwan

• Published in: Diagnostic microbiology and infectious disease 2006-06, Vol.55 (2), p.149-155
• Main Authors: Lauderdale, Tsai-Ling, Aarestrup, Frank M., Chen, Pei-Chen, Lai, Jui-Fen, Wang, Hui-Ying, Shiau, Yih-Ru, Huang, I-Wen, Hung, Che-Lun
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Humans; Multidrug resistance; Penta-resistance; Salmonella; Salmonella - classification; Salmonella - drug effects; Salmonella choleraesuis; Salmonella enterica; Salmonella Infections - epidemiology; Salmonella Infections - microbiology; Serotypes; Serotyping; Taiwan - epidemiology
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/j.diagmicrobio.2006.01.002

Of the 798 clinical Salmonella isolates collected from multiple hospitals in Taiwan, resistance to ampicillin (48.5%), chloramphenicol (55.3%), streptomycin (59.0%), sulfamethoxazole (68.0%), and tetracycline (67.8%) was high, whereas resistance to all 5 antimicrobials (ACSSuT R-type) comprised 327 (41%) and was highly prevalent in Salmonella enterica serotype Typhimurium (72.7%, 176/242), the most common serotype. Additional resistance to trimethoprim was present in 155 (19.4% overall) of the ACSSuT R-type isolates from several serotypes. Reduced susceptibility to fluoroquinolone (FQ) (ciprofloxacin MIC >0.125–1 μg/mL and nalidixic acid-resistant) was detected in 223 (27.9%) isolates including 117 (14.7% overall) that were also ACSSuT-resistant. Full resistance to FQ was detected in Salmonella Choleraesuis (35.5%, 6/17) and Salmonella Schwarzengrund (16.7%, 10/60); both serotypes were also multiresistant to other antimicrobials. Studies are needed to determine the sources of different multidrug-resistant serotypes. Continued national surveillance is underway to monitor changes in resistance trends and to detect further emergence of resistant Salmonella serotypes in Taiwan.