Gene-gene interactions in myocardial infarction

In their case-control meta-analysis, Ye and colleagues did not include reports focusing on gene-gene or gene-environment interactions. In a Newfoundland and Labrador population, the prothrombin 20210A polymorphism conferred a 3.2-fold increased risk of myocardial infarction, but combined carriage of...

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Bibliographic Details
Published in:The Lancet (British edition) 2006-05, Vol.367 (9524), p.1729-1730
Main Authors: Pernod, Gilles, Ormezzano, Olivier, Vanzetto, Gérald
Format: Article
Language:English
Subjects:
Factor VIII - genetics
Genetic Predisposition to Disease
Genetic research
Genotype-environment interactions
Heart attacks
Humans
Myocardial infarction
Myocardial Infarction - genetics
Polymorphism, Genetic
Prothrombin - genetics
Synergistic effect
Systematic review
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Summary:In their case-control meta-analysis, Ye and colleagues did not include reports focusing on gene-gene or gene-environment interactions. In a Newfoundland and Labrador population, the prothrombin 20210A polymorphism conferred a 3.2-fold increased risk of myocardial infarction, but combined carriage of this polymorphism and the factor XIII 34Leu allele had a synergistic effect, giving a 12-fold increased risk of myocardial infarction.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(06)68766-7