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p27(Kip1) and stathmin share the stage for the first time

Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27(Kip1) and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27(...

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Published in:Trends in cell biology 2005-07, Vol.15 (7), p.346-348
Main Authors: Iancu-Rubin, Camelia, Atweh, George F
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Language:English
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Atweh, George F
description Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27(Kip1) and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27(Kip1) and stathmin in the same pathway by showing that stathmin, a microtubule-regulatory protein, mediates the effects of p27(Kip1) on cell motility. These findings provide new insights into migration and metastasis of tumor cells and the relationship of these processes to cell proliferation.
doi_str_mv 10.1016/j.tcb.2005.05.008
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subjects Animals
Cell Cycle Proteins - pharmacology
Cell Cycle Proteins - physiology
Cell Movement - drug effects
Cell Movement - physiology
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p27
Humans
Microtubule Proteins - metabolism
Microtubule Proteins - physiology
Neoplasm Metastasis
Phosphoproteins - metabolism
Phosphoproteins - physiology
Protein Binding
Stathmin
Tumor Suppressor Proteins - pharmacology
Tumor Suppressor Proteins - physiology
title p27(Kip1) and stathmin share the stage for the first time
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