Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes

In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extrac...

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Published in:Diabetes research and clinical practice 2005-08, Vol.69 (2), p.175-179
Main Authors: Lee, Seung Won, Song, Kyoung Eun, Shin, Dong Sun, Ahn, Sung Min, Ha, Eun Suk, Kim, Dae Jung, Nam, Moon Suk, Lee, Kwan-Woo
Format: Article
Language:English
Subjects:
Blood Pressure
C-Reactive Protein - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - enzymology
Female
Homeostasis
hs-CRP
Humans
Intercellular adhesion molecule 1
Lipids - blood
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Metalloproteinases
Middle Aged
Reference Values
Smoking
Tissue Inhibitor of Metalloproteinase-1 - blood
Tissue inhibitors of metalloproteinase 1
Type-2 diabetes
Vascular cell adhesion molecule 1
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Summary:In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover. We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls. In addition, we determined the plasma levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and high sensitive(hs) C-reactive protein (CRP) in both groups. Plasma MMP-2, TIMP-1, and hs-CRP concentrations were significantly elevated in diabetic patients as compared to the control subjects ( p < 0.05). Plasma levels of MMP-2, MMP-9, TIMP-1, VCAM-1, ICAM-1, and hs-CRP were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations. Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2004.12.010