Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma

Osteosarcoma (OS) is the most common malignant bone tumor in children. To identify a plasma proteomic signature that can detect OS, we used SELDI MS to perform proteomic profiling on plasma specimens from 29 OS and 20 age‐matched osteochondroma (OC) patients. Nineteen statistically significant ion p...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2006-06, Vol.6 (11), p.3426-3435
Main Authors: Li, Yiting, Dang, Tu Anh, Shen, Jianhe, Perlaky, Laszlo, Hicks, John, Murray, Jeffrey, Meyer, William, Chintagumpala, Murali, Lau, Ching C., Man, Tsz-Kwong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers, Tumor - blood
Blood Proteins - analysis
Bone Neoplasms - diagnosis
Bone Neoplasms - metabolism
Child
Diagnosis, Differential
Diseases of the osteoarticular system
Fundamental and applied biological sciences. Psychology
Humans
Medical sciences
Miscellaneous
Molecular classification
Osteochondroma - diagnosis
Osteosarcoma
Osteosarcoma - diagnosis
Osteosarcoma - metabolism
Protein Array Analysis
Proteins
Proteome - analysis
SELDI
Serum amyloid protein A
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tumors of striated muscle and skeleton
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Summary:Osteosarcoma (OS) is the most common malignant bone tumor in children. To identify a plasma proteomic signature that can detect OS, we used SELDI MS to perform proteomic profiling on plasma specimens from 29 OS and 20 age‐matched osteochondroma (OC) patients. Nineteen statistically significant ion peaks that were differentially expressed in OS when compared with OC patients were identified (p 
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.200500472