The growth hormone 1 GH1:c.457C>G mutation is associated with intramuscular and rump fat distribution in a large sample of Australian feedlot cattle

Summary The GH1:c.457C>G exon 5 missense mutation in the bovine growth hormone 1 (GH1) gene that causes the replacement of leucine (L) with valine (V) was investigated in 1027 cattle with primarily Angus and Shorthorn breeding from Australian feedlots. The allele frequency of the GH1:c.457C allel...

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Bibliographic Details
Published in:Animal genetics 2006-06, Vol.37 (3), p.211-214
Main Authors: Barendse, W., Bunch, R. J., Harrison, B. E., Thomas, M. B.
Format: Article
Language:English
Subjects:
Alleles
Animals
Australia
Body Composition - genetics
Body Fat Distribution
Bos
cattle
Cattle - genetics
DNA
fat deposition
fat depots
Gene Frequency
Genotype
growth hormone
Growth Hormone - genetics
marbling
Mutation
Polymorphism, Single Nucleotide
rump fat
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Summary:Summary The GH1:c.457C>G exon 5 missense mutation in the bovine growth hormone 1 (GH1) gene that causes the replacement of leucine (L) with valine (V) was investigated in 1027 cattle with primarily Angus and Shorthorn breeding from Australian feedlots. The allele frequency of the GH1:c.457C allele was 0.77 in Angus and 0.76 in Shorthorn. The GH1:c.457C allele was associated with lower marbling (P = 0.0472), and the average effect of allele substitution was −0.22 of a phenotypic standard deviation. This allele was also associated with slightly higher rump fat (P = 0.0541) and the average effect of allele substitution was 0.11 SD. Marbling and rump fat were not strongly correlated (r = 0.097, P  0.1). Given these relationships, the differences between GH1 alleles could be the result of differential deposition of fat in fat depots.
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2006.01432.x