genome scan for quantitative trait loci associated with body weight at different developmental stages in chickens

• Published in: Animal genetics 2006-06, Vol.37 (3), p.276-278
• Main Authors: Gao, Y, Hu, X.X, Du, Z.Q, Deng, X.M, Huang, Y.H, Fei, J, Feng, J.D, Liu, Z.L, Da, Y, Li, N
• Format: Article
• Language: English
• Subjects: Animals; body weight; Body Weight - genetics; Breeding; chicken; chickens; Chickens - genetics; Chickens - growth & development; Chromosomes; developmental quantitative trait loci; developmental stages; Gallus gallus; genes; genetic variation; genome scan; Genomics; Genotype; liveweight gain; Microsatellite Repeats; molecular sequence data; phenotypic variation; Quantitative Trait Loci; Regression Analysis; Sequence Analysis, DNA; static quantitative trait loci
• ISSN: 0268-9146; 1365-2052
• DOI: 10.1111/j.1365-2052.2006.01428.x

A genome scan to detect quantitative trait loci (QTL) affecting body weight in chickens was conducted on 238 F₂ chickens from a reciprocal cross of Silky Fowl and White Plymouth Rock using 125 microsatellite markers covering 23 autosomes and the Z chromosome. Two types of QTL were considered: static QTL (SQ) and developmental QTL (DQ). Static QTL affected the body weight from hatch to time t, and DQ affected the body weight from time t-1 to time t. Six SQ and nine DQ were detected. Of these QTL, four reached a genome-wide significance of 5% or better, with SQ1 and DQ1 being the most significant QTL. Static QTL1 was on chromosome 1 between GCT0006 and MCW0106 and explained 4.05-9.80% of the phenotypic variation in body weights from 3 to 12 weeks of age. At 9, 10 and 11 weeks, the genome-wide significance thresholds of SQ1 were