Mechanisms of general anesthesia: from molecules to mind

Despite the widespread presence of clinical anesthesiology in medical practice, the mechanism by which diverse inhalational agents result in the state of general anesthesia remains unknown. Over recent decades, our understanding of general anesthetic mechanisms has evolved dramatically from early un...

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Bibliographic Details
Published in:Best practice & research. Clinical anaesthesiology 2005-09, Vol.19 (3), p.349-364
Main Authors: Mashour, George A., Forman, Stuart A., Campagna, Jason A.
Format: Article
Language:English
Subjects:
Anesthesia, General
Anesthetics, Inhalation - pharmacology
Animals
Brain - drug effects
Brain Chemistry - drug effects
Brain Chemistry - genetics
General anesthesia
general anesthetics
Health aspects
Humans
mechanism of anesthesia
theories of anesthesia
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Summary:Despite the widespread presence of clinical anesthesiology in medical practice, the mechanism by which diverse inhalational agents result in the state of general anesthesia remains unknown. Over recent decades, our understanding of general anesthetic mechanisms has evolved dramatically from early unitary hypotheses, largely due to the development and influence of a myriad of scientific disciplines ranging from molecular biology to cognitive neuroscience. These discoveries have led to a renaissance of investigation into the mechanisms of general anesthetics and have generated both novel answers and questions. In this chapter, we review the major hypotheses of general anesthetic mechanisms of action and present an expanded overview of current investigation into those mechanisms. We also present a framework to aid in thinking about the actions of these agents, highlighting the relationship between putative targets at the molecular level and the more integrated functional changes in behavior and consciousness.
ISSN:1521-6896
1532-169X
DOI:10.1016/j.bpa.2005.01.004