Presence of Host Immunoglobulin in the Gut of Sarcoptes scabiei (Acari: Sarcoptidae)

Sarcoptes scabiei (De Geer) mites burrow in the nonliving stratum corneum of the epidermis of their mammalian hosts. These mites ingest extracellular fluid (serum) that seeps into the burrow from the lower vascular dermis. A strong host antibody response occurs when mites die in the skin. This sugge...

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Bibliographic Details
Published in:Journal of medical entomology 2006-05, Vol.43 (3), p.539-542
Main Authors: RAPP, CHRISTINE M., MORGAN, MARJORIE S., ARLIAN, LARRY G.
Format: Article
Language:English
Subjects:
Animals
antibodies
antibody
Arachnida
ARTHROPOD/HOST INTERACTION, IMMUNITY
Biological and medical sciences
digestive tract
Epidermis - parasitology
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - immunology
host antibodies
immune response
immunoglobulin
immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulins - analysis
immunolocalization
ingestion
Invertebrates
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
midgut
mites
Rabbits
Sarcoptes scabiei
Sarcoptes scabiei - immunology
Sarcoptes scabiei - physiology
scabies
vaccine
Vectors. Intermediate hosts
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Summary:Sarcoptes scabiei (De Geer) mites burrow in the nonliving stratum corneum of the epidermis of their mammalian hosts. These mites ingest extracellular fluid (serum) that seeps into the burrow from the lower vascular dermis. A strong host antibody response occurs when mites die in the skin. This suggests internal immunogenic proteins are released into the host at this time. Vaccination with internal antigens may be an approach to protect against this mite if host antibody to internal antigens that regulate key physiological processes is ingested along with serum. Our study clearly showed that scabies mites ingest host immunoglobulin as evidenced by the localization of fluorescent-labeled antibody to host immunoglobulin in the anterior midgut and esophagus of fresh mites removed from the host. This is the first study that demonstrates that this nonblood-feeding ectoparasitic mite ingests host antibody while feeding on tissue fluid that seeps into the stratum corneum.
ISSN:0022-2585
1938-2928
DOI:10.1603/0022-2585%282006%2943%5B539%3APOHIIT%5D2.0.CO%3B2