Enhancing immune responses against a plasmid DNA vaccine encoding a FMDV empty capsid from serotype O

Various parameters have been examined for the improvement of immune responses induced by immunisation with foot-and-mouth disease virus (FMDV) DNA vaccine (pcDNA 3.1/P1-2A3C3D, P1) in swine. Our findings show that increasing the amount of P1 DNA plasmids and pGMCSF adjuvant plasmids induces stronger...

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Bibliographic Details
Published in:Vaccine 2006-05, Vol.24 (21), p.4602-4606
Main Authors: Li, Yanmin, Aggarwal, Neeraj, Takamatsu, Haru-H., Sterling, Catrina M.A., Voyce, Charlotte, Barnett, Paul V.
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Capsid
Cytokine
Cytokines - biosynthesis
Deoxyribonucleic acid
DNA
DNA vaccine
FMDV
Foot & mouth disease
Foot-and-mouth disease virus
Foot-and-Mouth Disease Virus - immunology
Hogs
Immunization
Neutralization Tests
Plasmids
Vaccines
Vaccines, DNA - immunology
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Summary:Various parameters have been examined for the improvement of immune responses induced by immunisation with foot-and-mouth disease virus (FMDV) DNA vaccine (pcDNA 3.1/P1-2A3C3D, P1) in swine. Our findings show that increasing the amount of P1 DNA plasmids and pGMCSF adjuvant plasmids induces stronger FMDV specific and neutralising antibody responses, as well as promoting cytokines IL-8 and IFNγ secretion, in immunised pigs via multiple inoculation sites.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.08.032