c- myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers

c- myc and HER2 amplification were analyzed on 214 consecutive breast cancers by fluorescence in situ hybridization using tissue microarray technology. The frequencies of amplification were 15.4% (33/214) and 23.3% (49/210), respectively. c- myc amplification was significantly associated with HER2 a...

Full description

Saved in:
Bibliographic Details
Published in:Human pathology 2005-06, Vol.36 (6), p.634-639
Main Authors: Park, Kyeongmee, Kwak, Keumhee, Kim, Jungyeon, Lim, Sungjig, Han, Sehwan
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - mortality
c- myc
Cell Proliferation
Disease-Free Survival
Female
Gene Amplification
Gynecology. Andrology. Obstetrics
HER2
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Investigative techniques, diagnostic techniques (general aspects)
Lymphatic Metastasis - genetics
Mammary gland diseases
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prognosis
Proto-Oncogene Proteins c-myc - genetics
Receptor, ErbB-2 - genetics
Survival Analysis
Tissue microarray
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:c- myc and HER2 amplification were analyzed on 214 consecutive breast cancers by fluorescence in situ hybridization using tissue microarray technology. The frequencies of amplification were 15.4% (33/214) and 23.3% (49/210), respectively. c- myc amplification was significantly associated with HER2 amplification ( P < .001) and closely linked with cell proliferative activity, measured by Ki67 labeling index ( P = .010). In univariate survival analysis, lymph node status, tumor size, and histological grade were significant prognostic factors, but in multivariate analysis, lymph node status was the only significant factor. Patient survival did not differ according to c- myc amplification status, and c- myc amplification showed no significant correlation with clinicopathologic features of the tumors. A strong correlation between c- myc and HER2 amplification and proliferative activity indicates a biological link between these genes in breast cancer cell.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2005.04.016