Combined Effect of the Metabolic Syndrome and Hostility on the Incidence of Myocardial Infarction (The Normative Aging Study)

A growing body of evidence suggests that the metabolic syndrome and hostility are independent risk factors for the development of coronary heart disease. However, few studies have examined the combined effect of the metabolic syndrome and hostility on the incidence of myocardial infarction (MI). We...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2005-07, Vol.96 (2), p.221-226
Main Authors: Todaro, John F., Con, Andrea, Niaura, Raymond, Spiro, Avron, Ward, Kenneth D., Roytberg, Anna
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Biological and medical sciences
Cardiology. Vascular system
Cohort Studies
Comorbidity
Coronary heart disease
Emotions
Female
Follow-Up Studies
Heart
Heart attacks
Hostility
Humans
Logistic Models
Male
Medical disorders
Medical sciences
Metabolic diseases
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Metabolism
Middle Aged
Miscellaneous
Multivariate Analysis
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Myocarditis. Cardiomyopathies
Other metabolic disorders
Probability
Prospective Studies
Psychology
Reference Values
Risk Assessment
Risk factors
Sex Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A growing body of evidence suggests that the metabolic syndrome and hostility are independent risk factors for the development of coronary heart disease. However, few studies have examined the combined effect of the metabolic syndrome and hostility on the incidence of myocardial infarction (MI). We examined prospectively the relation among the metabolic syndrome, hostility, and the incidence of MI in healthy, older men (mean ± SD 59.7 ± 7.2 years) who participated in the Normative Aging Study. Seven hundred fifty-four men who were diagnosed as not having coronary heart disease and diabetes mellitus were included in the present study. Men were assigned to 1 of 4 risk-factor groups based on the presence or absence of the metabolic syndrome and low or high hostility. Hierarchical logistic regression was used to assess the multivariate risk of developing a MI. The incidence of MI was 11.3% (n = 85) over an average follow-up period of 13.8 years. After adjusting for potential covariates, risk-factor group significantly predicted the incidence of MI (odds ratio 1.59, 95% confidence interval 1.29 to 1.96, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.03.049