Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis

Aims To evaluate the value of 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) in detecting cardiac sarcoidosis. Methods and results Thirty-two patients with sarcoidosis and thirty controls were recruited. All subjects underwent cardiac 18F-FDG PET after a 6 h fasting period, and...

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Published in:European heart journal 2005-08, Vol.26 (15), p.1538-1543
Main Authors: Ishimaru, Shinji, Tsujino, Ichizo, Takei, Toshiki, Tsukamoto, Eriko, Sakaue, Shinji, Kamigaki, Mitsunori, Ito, Naofumi, Ohira, Hiroshi, Ikeda, Daisuke, Tamaki, Nagara, Nishimura, Masaharu
Format: Article
Language:English
Subjects:
18F-FDG PET
67Ga scintigraphy
99mTc-sestamibi scintigraphy
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathies - diagnostic imaging
Case-Control Studies
Female
Fluorodeoxyglucose F18
Heart
Humans
Male
Medical sciences
Middle Aged
Positron-Emission Tomography - methods
Radiopharmaceuticals
Sarcoidosis
Sarcoidosis - diagnostic imaging
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Technetium Tc 99m Sestamibi
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Summary:Aims To evaluate the value of 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) in detecting cardiac sarcoidosis. Methods and results Thirty-two patients with sarcoidosis and thirty controls were recruited. All subjects underwent cardiac 18F-FDG PET after a 6 h fasting period, and subjects with sarcoidosis underwent blood testing, ECG, echocardiography, and 67Ga and 99mTc-sestamibi (MIBI) scintigraphy. We classified 18F-FDG PET images into four patterns (‘none’, ‘diffuse’, ‘focal’, and ‘focal on diffuse’) and found that all the control subjects exhibited either none (n=16) or diffuse (n=14) pattern. In contrast, fifteen subjects with sarcoidosis exhibited none, seven exhibited diffuse, eight exhibited focal, and two exhibited focal on diffuse patterns, with the prevalence of the focal and focal on diffuse patterns being significantly higher in the sarcoidosis group when compared with the control group (P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehi180