Determination of glycerophosphate and other anions in dentifrices by ion chromatography

Simple, reliable and sensitive analytical methods to determine the anions, such as fluoride, monofluorophaosphate, glycerophosphate related to anticaries are necessary for basic investigations of anticaries and quality control of dentifrices. A method for the simultaneous determination of organic ac...

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Bibliographic Details
Published in:Journal of Chromatography A 2006-06, Vol.1118 (1), p.155-159
Main Authors: Chen, Yongxin, Ye, Mingli, Cui, Hairong, Wu, Feiyan, Zhu, Yan, Fritz, James S.
Format: Article
Language:English
Subjects:
Analytical chemistry
Anions
Anions - analysis
Applied sciences
Calcium glycerophosphate
Chemical industry and chemicals
Chemistry
Chlorides - analysis
Chromatographic methods and physical methods associated with chromatography
Chromatography, Ion Exchange - methods
Cosmetics, toiletries
Dentifrices - chemistry
Exact sciences and technology
Fluoride
Fluorides - analysis
Glycerophosphates - analysis
Ion chromatography
Monofluorophaosphate
Nitrates - analysis
Nitrites - analysis
Other chromatographic methods
Oxalic Acid - analysis
Phosphates - analysis
Reproducibility of Results
Sulfates - analysis
Toothpastes - chemistry
Washing products. Cosmetics and toiletries. Perfumes
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Summary:Simple, reliable and sensitive analytical methods to determine the anions, such as fluoride, monofluorophaosphate, glycerophosphate related to anticaries are necessary for basic investigations of anticaries and quality control of dentifrices. A method for the simultaneous determination of organic acids, organic anions and inorganic anions in the sample of commercial toothpaste is proposed. Nine anions (fluoride, chloride, nitrite, nitrate, sulfate, phosphate, monofluorophaosphate, glycerophosphate and oxalic acid) were analyzed by means of ion chromatography using a gradient elution with KOH as mobile phase, IonPac AS18 as the separation column and suppressed conductivity detection. Optimized analytical conditions were further validated in terms of accuracy, precision and total uncertainty and the results showed the reliability of the IC method. The relative standard deviations (RSD) of the retention time and peak area of all species were less than 0.170 and 1.800%, respectively. The correlation coefficients for target analytes ranged from 0.9985 to 0.9996. The detection limit (signal to noise ratio of 3:1) of this method was at low ppb level (
ISSN:0021-9673
DOI:10.1016/j.chroma.2006.01.137