High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease

We screened 134 consecutive patients with von Willebrand disease (VWD) (106 type 1, 26 type 2, and 2 type 3 VWD) for the most important inherited prothrombotic risk factors. One hundred eight patients (80.6%) weree positive for at least one of the prothrombotic risk factors screened for. A high prev...

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Bibliographic Details
Published in:American journal of hematology 2006-06, Vol.81 (6), p.465-467
Main Authors: Franchini, Massimo, Veneri, Dino, Poli, Giovanni, Manzato, Franco, Salvagno, Gian Luca, Lippi, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
bleeding
Factor V - genetics
Female
Gene Frequency - genetics
Hematologic and hematopoietic diseases
Hemorrhage - genetics
Humans
Male
Medical sciences
Platelet diseases and coagulopathies
Point Mutation
Prevalence
Prothrombin - genetics
Risk Factors
thrombosis
Thrombosis - genetics
von Willebrand disease
von Willebrand Diseases - genetics
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Summary:We screened 134 consecutive patients with von Willebrand disease (VWD) (106 type 1, 26 type 2, and 2 type 3 VWD) for the most important inherited prothrombotic risk factors. One hundred eight patients (80.6%) weree positive for at least one of the prothrombotic risk factors screened for. A high prevalence of prothrombin G20210A (10.5%) and factor V Leiden (11.9%) mutations was found with allele frequencies of 5.2 and 6%, respectively. Three carriers of multiple prothrombotic gene mutations experienced a thrombotic event. Our study suggests that the recent evidence of an association between inherited thrombotic and hemorrhagic disorders also holds true in VWD patients. Am. J. Hematol. 81:465–467, 2006. © 2006 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20623