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High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease

We screened 134 consecutive patients with von Willebrand disease (VWD) (106 type 1, 26 type 2, and 2 type 3 VWD) for the most important inherited prothrombotic risk factors. One hundred eight patients (80.6%) weree positive for at least one of the prothrombotic risk factors screened for. A high prev...

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Published in:	American journal of hematology 2006-06, Vol.81 (6), p.465-467
Main Authors:	Franchini, Massimo, Veneri, Dino, Poli, Giovanni, Manzato, Franco, Salvagno, Gian Luca, Lippi, Giuseppe
Format:	Article
Language:	English
Subjects:	Adult Biological and medical sciences bleeding Factor V - genetics Female Gene Frequency - genetics Hematologic and hematopoietic diseases Hemorrhage - genetics Humans Male Medical sciences Platelet diseases and coagulopathies Point Mutation Prevalence Prothrombin - genetics Risk Factors thrombosis Thrombosis - genetics von Willebrand disease von Willebrand Diseases - genetics
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container_end_page	467
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container_title	American journal of hematology
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creator	Franchini, Massimo Veneri, Dino Poli, Giovanni Manzato, Franco Salvagno, Gian Luca Lippi, Giuseppe
description	We screened 134 consecutive patients with von Willebrand disease (VWD) (106 type 1, 26 type 2, and 2 type 3 VWD) for the most important inherited prothrombotic risk factors. One hundred eight patients (80.6%) weree positive for at least one of the prothrombotic risk factors screened for. A high prevalence of prothrombin G20210A (10.5%) and factor V Leiden (11.9%) mutations was found with allele frequencies of 5.2 and 6%, respectively. Three carriers of multiple prothrombotic gene mutations experienced a thrombotic event. Our study suggests that the recent evidence of an association between inherited thrombotic and hemorrhagic disorders also holds true in VWD patients. Am. J. Hematol. 81:465–467, 2006. © 2006 Wiley‐Liss, Inc.
doi_str_mv	10.1002/ajh.20623
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subjects	Adult Biological and medical sciences bleeding Factor V - genetics Female Gene Frequency - genetics Hematologic and hematopoietic diseases Hemorrhage - genetics Humans Male Medical sciences Platelet diseases and coagulopathies Point Mutation Prevalence Prothrombin - genetics Risk Factors thrombosis Thrombosis - genetics von Willebrand disease von Willebrand Diseases - genetics
title	High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease
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