Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients

Cyclin B1, identified as a regulator of late cell cycle, is involved in the development and progression of a variety of human malignancies. To clarify the role of cyclin B1 in the pathogenesis and prognosis of renal cell carcinoma (RCC), protein expression was compared with clinicopathological chara...

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Published in:International journal of cancer 2006-08, Vol.119 (4), p.867-874
Main Authors: Ikuerowo, Stephen O., Kuczyk, Markus A., Mengel, Michael, van der Heyde, Eyck, Shittu, Olayiwola B., Vaske, Bernhard, Jonas, Udo, Machtens, Stefan, Serth, Jürgen
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Cyclin B - metabolism
Cyclin B1
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Kidneys
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness - pathology
Nephrology. Urinary tract diseases
prognosis
renal cell carcinoma
Subcellular Fractions - metabolism
Survival Rate
Tumors
Tumors of the urinary system
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creator Ikuerowo, Stephen O.
Kuczyk, Markus A.
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Vaske, Bernhard
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Machtens, Stefan
Serth, Jürgen
description Cyclin B1, identified as a regulator of late cell cycle, is involved in the development and progression of a variety of human malignancies. To clarify the role of cyclin B1 in the pathogenesis and prognosis of renal cell carcinoma (RCC), protein expression was compared with clinicopathological characteristics of patients as well as the long‐term survival after surgical therapy. Expression analysis was carried out by immunohistochemistry and tissue microarray analysis. The microarrays that represented the primary tumors, their invasion front and normal peritumoral renal parenchyma contained 753 tissue cores obtained from 251 randomly selected nephrectomy specimens. Immunopositivity within the primary tumors was significantly associated with tumor stage (pT) (p < 0.01), lymph node status (pN) (p < 0.01) as well as the presence of systemic metastatic disease (p = 0.01). Subcellular expression in the cytoplasm of tumor cells significantly correlated with pT (p = 0.02) and pN (p = 0.03). When peritumoral tissue samples exhibited a relative amount of
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To clarify the role of cyclin B1 in the pathogenesis and prognosis of renal cell carcinoma (RCC), protein expression was compared with clinicopathological characteristics of patients as well as the long‐term survival after surgical therapy. Expression analysis was carried out by immunohistochemistry and tissue microarray analysis. The microarrays that represented the primary tumors, their invasion front and normal peritumoral renal parenchyma contained 753 tissue cores obtained from 251 randomly selected nephrectomy specimens. Immunopositivity within the primary tumors was significantly associated with tumor stage (pT) (p &lt; 0.01), lymph node status (pN) (p &lt; 0.01) as well as the presence of systemic metastatic disease (p = 0.01). Subcellular expression in the cytoplasm of tumor cells significantly correlated with pT (p = 0.02) and pN (p = 0.03). When peritumoral tissue samples exhibited a relative amount of &lt;10% of positively reacting epithelial cells, cyclin B positivity was identified to predict long‐term survival of patients in univariate analysis (p &lt; 0.01) whereas borderline significance was observed in multivariate statistical analysis (p = 0.05). Increased intratumoral cyclin B1 positivity and aberrant localization of signals within the cytoplasm of tumor cells is positively correlated with the tendency towards tumor progression, indicating the significant role of cyclin B1 in the development and pathogenesis of RCC. 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To clarify the role of cyclin B1 in the pathogenesis and prognosis of renal cell carcinoma (RCC), protein expression was compared with clinicopathological characteristics of patients as well as the long‐term survival after surgical therapy. Expression analysis was carried out by immunohistochemistry and tissue microarray analysis. The microarrays that represented the primary tumors, their invasion front and normal peritumoral renal parenchyma contained 753 tissue cores obtained from 251 randomly selected nephrectomy specimens. Immunopositivity within the primary tumors was significantly associated with tumor stage (pT) (p &lt; 0.01), lymph node status (pN) (p &lt; 0.01) as well as the presence of systemic metastatic disease (p = 0.01). Subcellular expression in the cytoplasm of tumor cells significantly correlated with pT (p = 0.02) and pN (p = 0.03). 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subjects Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Cyclin B - metabolism
Cyclin B1
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Kidneys
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness - pathology
Nephrology. Urinary tract diseases
prognosis
renal cell carcinoma
Subcellular Fractions - metabolism
Survival Rate
Tumors
Tumors of the urinary system
title Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients
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