Direct measurement of nipradilol-derived nitric oxide in the vascular wall of canine femoral arteries

Nipradilol (NP: 3,4-dihydro-8-[2-hydroxy-3-isopropylamino]propoxy-3-nitroxy-2H-1-benzopyran) shows not only beta-adrenoreceptor-blocking effects but also nitroglycerin-like vasodilatory action. We aimed to directly measure NP-derived nitric oxide (NO) in the vascular wall. An NO-sensitive microelect...

Full description

Saved in:
Bibliographic Details
Published in:Heart and vessels 2005-07, Vol.20 (4), p.175-178
Main Authors: Mochizuki, Seiichi, Chiba, Yoko, Hiramatsu, Osamu, Tachibana, Hiroyuki, Nakamoto, Hiroshi, Toyota, Eiji, Ogasawara, Yasuo, Kajiya, Fumihiko
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Beta blockers
Coronary vessels
Dogs
Femoral Artery - metabolism
In Vitro Techniques
Measurement techniques
Medical research
Metabolism
Microelectrodes
Nitric oxide
Nitric Oxide - metabolism
Propanolamines - pharmacology
Vasodilator Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nipradilol (NP: 3,4-dihydro-8-[2-hydroxy-3-isopropylamino]propoxy-3-nitroxy-2H-1-benzopyran) shows not only beta-adrenoreceptor-blocking effects but also nitroglycerin-like vasodilatory action. We aimed to directly measure NP-derived nitric oxide (NO) in the vascular wall. An NO-sensitive microelectrode was inserted into the vascular media (the vasodilatory action site of NO) of isolated perfused canine femoral arteries. Each vessel was perfused with 15 microM NP in the presence or absence of 1 mM N-ethylmaleimide (NEM; a thiol alkylator). Intravascular-wall NO concentration increased 181+/-34 nM during NP perfusion (P
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-005-0827-7