Exploring molecular networks using MONET ontology

The description of the complex molecular network responsible for cell behavior requires new tools to integrate large quantities of experimental data in the design of biological information systems. These tools could be used in the characterization of these networks and in the formulation of relevant...

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Bibliographic Details
Published in:Genetics and molecular research 2006-01, Vol.5 (1), p.182-192
Main Authors: Silva, João Paulo Müller da, Lemke, Ney, Mombach, José Carlos, Souza, José Guilherme Camargo de, Sinigaglia, Marialva, Vieira, Renata
Format: Article
Language:English
Subjects:
Computational Biology - methods
Computer Communication Networks
Databases, Genetic
Molecular Biology
Systems Integration
Online Access:Get full text
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Summary:The description of the complex molecular network responsible for cell behavior requires new tools to integrate large quantities of experimental data in the design of biological information systems. These tools could be used in the characterization of these networks and in the formulation of relevant biological hypotheses. The building of an ontology is a crucial step because it integrates in a coherent framework the concepts necessary to accomplish such a task. We present MONET (molecular network), an extensible ontology and an architecture designed to facilitate the integration of data originating from different public databases in a single- and well-documented relational database, that is compatible with MONET formal definition. We also present an example of an application that can easily be implemented using these tools.
ISSN:1676-5680
1676-5680