Associations Between Serum Resistin Levels and Insulin Resistance, Inflammation and Coronary Artery Disease

Patients with one-vessel, two-vessel, and three-vessel disease more often showed a resistin level of >6.0 ng/ml than those without CAD (25%, 29%, and 39% vs. 5%; p < 0.01). [...]resistin levels correlated with the numbers of >50% stenotic segments (r = 0.20) and >25% stenotic segments (r...

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Published in:Journal of the American College of Cardiology 2005-07, Vol.46 (2), p.379-380
Main Authors: Ohmori, Reiko, PhD, Momiyama, Yukihiko, MD, Kato, Ryuichi, MD, Taniguchi, Hiroaki, MD, Ogura, Masatsune, MD, Ayaori, Makoto, MD, Nakamura, Haruo, MD, Ohsuzu, Fumitaka, MD, FACC
Format: Article
Language:English
Subjects:
Aged
C-Reactive Protein - metabolism
Cardiology
Cardiovascular
Cholesterol
Coronary Artery Disease - blood
Coronary vessels
Female
Heart attacks
Hormones, Ectopic - blood
Humans
Inflammation - blood
Insulin
Insulin Resistance
Logistic Models
Male
Middle Aged
Obesity
Resistin
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Summary:Patients with one-vessel, two-vessel, and three-vessel disease more often showed a resistin level of >6.0 ng/ml than those without CAD (25%, 29%, and 39% vs. 5%; p < 0.01). [...]resistin levels correlated with the numbers of >50% stenotic segments (r = 0.20) and >25% stenotic segments (r = 0.21) (p < 0.005 by Spearman's rank correlation). Because insulin resistance became recognized to be associated with atherosclerotic disease and because atherosclerosis is recognized as a chronic inflammatory disease, resistin may play some role in linking insulin resistance and inflammation to CAD.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2005.04.022