CYSTIC FIBROSIS SPUTUM STIMULATES CD18-INDEPENDENT NEUTROPHIL MIGRATION ACROSS ENDOTHELIAL CELLS

Excessive neutrophil recruitment to the lung underlies inflammatory-mediated lung damage in cystic fibrosis (CF). Neutrophils can migrate to the lung using either a CD18-dependent or CD18-independent mechanism. To determine if one of these migratory pathways is preferentially utilized by neutrophils...

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Bibliographic Details
Published in:Experimental lung research 2005-05, Vol.31 (4), p.377-390
Main Authors: Jill Mackarel, A., Plant, Barry J., FitzGerald, Muiris X., O'Connor, Clare M., Martin, Lorraine, Stuart Elborn, J., Gallagher, Charles G.
Format: Article
Language:English
Subjects:
Adult
CD18 Antigens - metabolism
Cell Movement - drug effects
Cells, Cultured
Chemotactic Factors - metabolism
Chemotactic Factors - pharmacology
Cystic fibrosis
Cystic Fibrosis - metabolism
Cystic Fibrosis - pathology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Female
Humans
interleukin-8
leukotriene B4
Male
neutrophil migration
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - pathology
Sputum - chemistry
Sputum - metabolism
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Summary:Excessive neutrophil recruitment to the lung underlies inflammatory-mediated lung damage in cystic fibrosis (CF). Neutrophils can migrate to the lung using either a CD18-dependent or CD18-independent mechanism. To determine if one of these migratory pathways is preferentially utilized by neutrophils migrating to the CF airways, this study examined the CD18 dependency of neutrophil transendothelial migration stimulated by the soluble fraction of CF sputum (SOL). Results demonstrate the preferential use of the CD18-independent migratory mechanism by both control and CF neutrophils and suggest that selective blocking of the CD18-independent migration pathway may offer a means of decreasing neutrophil influx to the CF airways.
ISSN:0190-2148
1521-0499
DOI:10.1080/019021490927060