Incorporating Serotypes into Family Based Association Studies Using the MFG Test

Summary Family based association tests are widely used to detect genetic effects. The focus of this paper is the maternal‐fetal genotype (MFG) incompatibility test, a family based association test which can be used to detect genetic effects that contribute to disease, including alleles in the child...

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Bibliographic Details
Published in:Annals of human genetics 2006-07, Vol.70 (4), p.541-553
Main Authors: Minassian, S. L., Palmer, C. G. S., Turunen, J. A., Paunio, T., Lönnqvist, J., Peltonen, L., Woodward, J. A., Sinsheimer, J. S.
Format: Article
Language:English
Subjects:
Blood Group Incompatibility - genetics
Blood Grouping and Crossmatching
Computer Simulation
Female
gene by environment
gene by gene
Genetic Linkage
Genotype
Histocompatibility Testing - methods
Humans
Likelihood Functions
Male
maternal‐fetal genotype incompatibility
missing data
Models, Genetic
non‐codominant data
Nuclear Family
Pregnancy
Rh-Hr Blood-Group System - blood
Rh-Hr Blood-Group System - genetics
rhesus incompatibility
Risk Factors
Sample Size
Schizophrenia - genetics
serotypes
Serotyping
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Summary:Summary Family based association tests are widely used to detect genetic effects. The focus of this paper is the maternal‐fetal genotype (MFG) incompatibility test, a family based association test which can be used to detect genetic effects that contribute to disease, including alleles in the child that increase disease risk, maternal alleles that increase disease risk in the child, and maternal‐fetal genotype incompatibilities. Consideration of incomplete data resulting from using serotypes could expand the power of the MFG test for detecting genetic effects. Serotypes may be all that are available in certain families, or preferred because of convenience or low cost, and thus a modification of the MFG test will allow optimal use of such data. The modified MFG likelihood can accommodate the incomplete data that result from using serotypes rather than the corresponding codominant genotypes. The modified MFG test was evaluated with serotypes and genotypes from families with members affected with schizophrenia. In addition, simulation studies were performed. Results of the data analyses and simulation studies showed that serotypes can be used to augment genotypes within a sample, to increase power to detect effects when the candidate gene produces serotypes.
ISSN:0003-4800
1469-1809
DOI:10.1111/j.1469-1809.2005.00243.x