Effect of eprosartan on the sympathetic response to cold pressor test in healthy volunteers

The aim of this study was to evaluate the effect of short-term administration of the AT 1 angiotensin II receptor antagonist, eprosartan, on the sympathetic response to cold pressor test (CPT) in normotensive healthy volunteers. Sixty-nine healthy volunteers were included in this double-blind placeb...

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Bibliographic Details
Published in:Autonomic neuroscience 2006-06, Vol.126, p.179-184
Main Authors: Israel, Anita, Zavala, Lida E., Cierco, Maria, Gutierrez, Antonio, del Rosario Garrido, Maria
Format: Article
Language:English
Subjects:
Acrylates - pharmacology
Administration, Oral
Adolescent
Adult
Analysis of Variance
Angiotensin II receptor antagonists
Angiotensin II Type 1 Receptor Blockers - pharmacology
Blood Pressure - drug effects
Blood Pressure - physiology
Blood Pressure - radiation effects
Cold pressor test
Cold Temperature
Double-Blind Method
Eprosartan
Female
Heart Rate - drug effects
Heart Rate - physiology
Humans
Imidazoles - pharmacology
Losartan
Losartan - pharmacology
Male
Middle Aged
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Thiophenes - pharmacology
Time Factors
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Summary:The aim of this study was to evaluate the effect of short-term administration of the AT 1 angiotensin II receptor antagonist, eprosartan, on the sympathetic response to cold pressor test (CPT) in normotensive healthy volunteers. Sixty-nine healthy volunteers were included in this double-blind placebo-controlled study. Blood pressure and heart rate were determined before and 175 min after oral administration of placebo, losartan (50 mg) or eprosartan (600 mg). Immediately, the subjects underwent CPT and then the same hemodynamic variables were measured. CPT increased arterial blood pressure (systolic, diastolic and mean) and HR in placebo-treated group. Pretreatment with a single dose of losartan or eprosartan blunted CPT-induced pressor response, but not the rise in heart rate. Our results demonstrate that endogenous angiotensin II, through stimulation of AT 1 receptor, supports sympathetic mediated stress-response in humans.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2006.02.020