C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia

The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-04, Vol.139 (4), p.421-423
Main Authors: Fadyukova, O E, Kadi, A, Bai, Ou, Andzhusheva, G M, Koshelev, V B
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - prevention & control
Neuroprotective Agents - pharmacology
Oligopeptides - pharmacology
Proline - analogs & derivatives
Proline - pharmacology
Rats
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Description
Summary:The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0311-5