Molecular magnetic resonance imaging of atrial clots in a swine model

The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots. Chro...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2005-07, Vol.112 (3), p.396-399
Main Authors: SPUENTRUP, Elmar, FAUSTEN, Bernd, BUSCH, Thomas, GÜNTHER, Rolf W, BUECKER, Arno, KINZEL, Sylvia, WIETHOFF, Andrea J, BOTNAR, Rene M, GRAHAM, Philip B, HALLER, Stephan, KATOH, Marcus, PARSONS, Edward C, MANNING, Warren J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Cardiology. Vascular system
Cardiovascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Heart Atria
Heart Diseases - diagnosis
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Medical sciences
Models, Animal
Pharmacology. Drug treatments
Radionuclide investigations
Swine
Thrombosis - diagnosis
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Summary:The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots. Chronic human thrombi were surgically implanted in the left atrial appendage of 5 swine. Molecular MRI was performed with a navigator-gated, free-breathing, cardiac-triggered 3D inversion-recovery, black-blood, gradient-echo sequence before and after systemic administration of 4 micromol/kg EP-2104R. MR images were analyzed by 2 investigators, and the contrast-to-noise ratio was calculated. Location of clots was confirmed by autopsy, and the gadolinium concentration in the clots was assessed. Before contrast agent administration, thrombi were not visible on black-blood MR images. After contrast administration, all atrial clots (n=5) were selectively visualized as white spots with a high contrast-to-noise ratio (clot/blood, 29.7+/-8.0). The gadolinium concentration in the clots averaged 74+/-45 micromol/L. The fibrin-specific MR contrast agent EP-2104R allows for selective and high-contrast visualization of left atrial clots by means of molecular targeted MRI.
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.104.529941