Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway

Farah S. L. Thong 1 , Chandrasagar B. Dugani 1 ,2 and Amira Klip 1 ,2 1 Programme in Cell Biology, The Hospital for Sick Children, and 2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada amira{at}sickkids.ca Insulin stimulation of glucose uptake into skeletal muscle and adi...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2005-08, Vol.20 (4), p.271-284
Main Authors: Thong, Farah S. L, Dugani, Chandrasagar B, Klip, Amira
Format: Article
Language:English
Subjects:
Animals
Glucose - metabolism
Glucose Transporter Type 4
Humans
Insulin - metabolism
Monosaccharide Transport Proteins - metabolism
Muscle Proteins - metabolism
Signal Transduction - physiology
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Summary:Farah S. L. Thong 1 , Chandrasagar B. Dugani 1 ,2 and Amira Klip 1 ,2 1 Programme in Cell Biology, The Hospital for Sick Children, and 2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada amira{at}sickkids.ca Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00017.2005