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Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway
Farah S. L. Thong 1 , Chandrasagar B. Dugani 1 ,2 and Amira Klip 1 ,2 1 Programme in Cell Biology, The Hospital for Sick Children, and 2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada amira{at}sickkids.ca Insulin stimulation of glucose uptake into skeletal muscle and adi...
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| Published in: | Physiology (Bethesda, Md.) Md.), 2005-08, Vol.20 (4), p.271-284 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c457t-fb72651bc12046b696d5f5352088d462c85ffa79ef137706a6930991cf0a2d8b3 |
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| cites | cdi_FETCH-LOGICAL-c457t-fb72651bc12046b696d5f5352088d462c85ffa79ef137706a6930991cf0a2d8b3 |
| container_end_page | 284 |
| container_issue | 4 |
| container_start_page | 271 |
| container_title | Physiology (Bethesda, Md.) |
| container_volume | 20 |
| creator | Thong, Farah S. L Dugani, Chandrasagar B Klip, Amira |
| description | Farah S. L. Thong 1 ,
Chandrasagar B. Dugani 1 ,2 and
Amira Klip 1 ,2
1 Programme in Cell Biology, The Hospital for Sick Children, and
2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
amira{at}sickkids.ca
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task. |
| doi_str_mv | 10.1152/physiol.00017.2005 |
| format | article |
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Amira Klip 1 ,2
1 Programme in Cell Biology, The Hospital for Sick Children, and
2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
amira{at}sickkids.ca
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.</description><identifier>ISSN: 1548-9213</identifier><identifier>EISSN: 1548-9221</identifier><identifier>DOI: 10.1152/physiol.00017.2005</identifier><identifier>PMID: 16024515</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Animals ; Glucose - metabolism ; Glucose Transporter Type 4 ; Humans ; Insulin - metabolism ; Monosaccharide Transport Proteins - metabolism ; Muscle Proteins - metabolism ; Signal Transduction - physiology</subject><ispartof>Physiology (Bethesda, Md.), 2005-08, Vol.20 (4), p.271-284</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-fb72651bc12046b696d5f5352088d462c85ffa79ef137706a6930991cf0a2d8b3</citedby><cites>FETCH-LOGICAL-c457t-fb72651bc12046b696d5f5352088d462c85ffa79ef137706a6930991cf0a2d8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16024515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thong, Farah S. L</creatorcontrib><creatorcontrib>Dugani, Chandrasagar B</creatorcontrib><creatorcontrib>Klip, Amira</creatorcontrib><title>Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway</title><title>Physiology (Bethesda, Md.)</title><addtitle>Physiology (Bethesda)</addtitle><description>Farah S. L. Thong 1 ,
Chandrasagar B. Dugani 1 ,2 and
Amira Klip 1 ,2
1 Programme in Cell Biology, The Hospital for Sick Children, and
2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
amira{at}sickkids.ca
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.</description><subject>Animals</subject><subject>Glucose - metabolism</subject><subject>Glucose Transporter Type 4</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins - metabolism</subject><subject>Signal Transduction - physiology</subject><issn>1548-9213</issn><issn>1548-9221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwyAch4nRuDn9Ah4MJ-Ol8w8ttPWkWdyLWbKD3ZnQFjZMR2tpo_v2dm5TL54g5Pk9CQ9C1wSGhDB6X623zpTFEABIOKQA7AT1CQsiL6aUnP7cid9DF869AfgsYvQc9QgHGjDC-uglaWtr7Aq_mpWVhcMLi6XN8ULrBzyZL5MAJ7XU2mTYWNysFZ5Z1xbGevvBbjo1q_WH3F6iM90Z1NXhHKDl-DkZTb35YjIbPc29LGBh4-k0pJyRNCMUAp7ymOdMM59RiKI84DSLmNYyjJUmfhgClzz2IY5JpkHSPEr9Abrde6u6fG-Va8TGuEwVhbSqbJ3gETCfRkEH0j2Y1aVztdKiqs1G1ltBQOwKikNB8V1Q7Ap2o5uDvU03Kv-dHJJ1wOMeWO--bWp1tJSrrRi3RZGoz-bPW2m7SIqCCAQNiahy3Snu_ldYUzlxxP0v2AmS5A</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Thong, Farah S. L</creator><creator>Dugani, Chandrasagar B</creator><creator>Klip, Amira</creator><general>Am Physiological Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway</title><author>Thong, Farah S. L ; Dugani, Chandrasagar B ; Klip, Amira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-fb72651bc12046b696d5f5352088d462c85ffa79ef137706a6930991cf0a2d8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Glucose - metabolism</topic><topic>Glucose Transporter Type 4</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Monosaccharide Transport Proteins - metabolism</topic><topic>Muscle Proteins - metabolism</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thong, Farah S. L</creatorcontrib><creatorcontrib>Dugani, Chandrasagar B</creatorcontrib><creatorcontrib>Klip, Amira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology (Bethesda, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thong, Farah S. L</au><au>Dugani, Chandrasagar B</au><au>Klip, Amira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway</atitle><jtitle>Physiology (Bethesda, Md.)</jtitle><addtitle>Physiology (Bethesda)</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>20</volume><issue>4</issue><spage>271</spage><epage>284</epage><pages>271-284</pages><issn>1548-9213</issn><eissn>1548-9221</eissn><abstract>Farah S. L. Thong 1 ,
Chandrasagar B. Dugani 1 ,2 and
Amira Klip 1 ,2
1 Programme in Cell Biology, The Hospital for Sick Children, and
2 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
amira{at}sickkids.ca
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>16024515</pmid><doi>10.1152/physiol.00017.2005</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1548-9213 |
| ispartof | Physiology (Bethesda, Md.), 2005-08, Vol.20 (4), p.271-284 |
| issn | 1548-9213 1548-9221 |
| language | eng |
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| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Animals Glucose - metabolism Glucose Transporter Type 4 Humans Insulin - metabolism Monosaccharide Transport Proteins - metabolism Muscle Proteins - metabolism Signal Transduction - physiology |
| title | Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway |
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