Signaling pathways in skeletal muscle remodeling

Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological and metabolic parameters. It is this diversity that enables different muscle groups to provide a variety of functional properties. In response to environmental demands, skeletal muscle remodels by activati...

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Bibliographic Details
Published in:Annual review of biochemistry 2006-01, Vol.75 (1), p.19-37
Main Authors: Bassel-Duby, Rhonda, Olson, Eric N
Format: Article
Language:English
Subjects:
Anabolic Agents - metabolism
Animal diseases
Animal models
Animals
Atrophy - metabolism
Calcineurin - metabolism
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Diabetes Mellitus, Type 2 - metabolism
Genetics
Genotype & phenotype
Histone Deacetylases - metabolism
Isoenzymes - metabolism
MEF2 Transcription Factors
Mitogen-Activated Protein Kinases - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - pathology
Muscle, Skeletal - physiology
Muscular Dystrophies - metabolism
Musculoskeletal system
Myofibrils - physiology
Myogenic Regulatory Factors - metabolism
NFATC Transcription Factors - metabolism
Obesity - metabolism
PPAR delta - metabolism
Protein Kinase C - metabolism
Protein Kinases - metabolism
ras Proteins - metabolism
Signal Transduction - physiology
Somatomedins - metabolism
Steroids - metabolism
TOR Serine-Threonine Kinases
Transcription Factors - metabolism
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Summary:Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological and metabolic parameters. It is this diversity that enables different muscle groups to provide a variety of functional properties. In response to environmental demands, skeletal muscle remodels by activating signaling pathways to reprogram gene expression to sustain muscle performance. Studies have been performed using exercise, electrical stimulation, transgenic animal models, disease states, and microgravity to show genetic alterations and transitions of muscle fibers in response to functional demands. Various components of calcium-dependent signaling pathways and multiple transcription factors, coactivators and corepressors have been shown to be involved in skeletal muscle remodeling. Understanding the mechanisms involved in modulating skeletal muscle phenotypes can potentiate the development of new therapeutic measures to ameliorate muscular diseases.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.biochem.75.103004.142622