Discontinuation of Primary Prophylaxis against Mycobacterium avium Complex Infection in HIV-Infected Persons Receiving Antiretroviral Therapy: Observations from a Large National Cohort in the United States, 1992–2002

In a large, diverse cohort of human immunodeficiency virus (HIV)-infected persons receiving routine care, the proportion of eligible persons who discontinued primary prophylaxis against Mycobacterium avium complex (MAC) infection, according to guidelines of the US Public Health Service and the Infec...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-08, Vol.41 (4), p.549-553
Main Authors: Brooks, John T., Song, Ruiguang, Hanson, Debra L., Wolfe, Mitchell, Swerdlow, David L.
Format: Article
Language:English
Subjects:
Adolescents
AIDS
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - prevention & control
Antibiotic Prophylaxis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiretrovirals
Antiviral agents
Bacterial diseases
Biological and medical sciences
CD4 Lymphocyte Count
Cohort Studies
Highly active antiretroviral therapy
HIV
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
Human bacterial diseases
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Medical treatment
Mycobacterium avium complex
Mycobacterium avium-intracellulare Infection - epidemiology
Mycobacterium avium-intracellulare Infection - prevention & control
Nadir
Pharmacology. Drug treatments
Practice Guidelines as Topic
Preventive medicine
Risk factors
Tuberculosis and atypical mycobacterial infections
United States
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:In a large, diverse cohort of human immunodeficiency virus (HIV)-infected persons receiving routine care, the proportion of eligible persons who discontinued primary prophylaxis against Mycobacterium avium complex (MAC) infection, according to guidelines of the US Public Health Service and the Infectious Diseases Society of America, increased from 16.7% (in 1996) to 84.9% (in 2002). The discontinuation of primary prophylaxis was not associated with an increased risk of disseminated MAC infection.
ISSN:1058-4838
1537-6591
DOI:10.1086/432057