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The prevalence of PIK3CA mutations in gastric and colon cancer
A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase ( PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 and 20 that has previously been reported as mutational hotspot regions in distinct tumour models. One hundred and fifty...
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Published in: | European journal of cancer (1990) 2005-07, Vol.41 (11), p.1649-1654 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A wide variety of tumours show
PIK3CA mutations leading to increased phosphatidylinositol-3 kinase (
PI3K) activity. We have determined the frequency of
PIK3CA mutations in exons 9 and 20 that has previously been reported as mutational hotspot regions in distinct tumour models. One hundred and fifty gastrointestinal carcinomas (47 gastric and 103 colorectal) that were characterised for MSI status (76 MSI and 74 MSS) by PCR-SSCP sequencing were evaluated. We also analysed the association between
PIK3CA mutations and
KRAS or
BRAF mutations.
PIK3CA mutations in exons 9 and 20 were present in 13.6% and 10.6% of colorectal and gastric carcinomas, respectively. No differences in frequency and type of
PIK3CA mutations were found between MSI and MSS colorectal carcinomas. All gastric carcinomas with
PIK3CA mutations were MSI. The number of cases harbouring concomitant
PIK3CA and
KRAS or
BRAF mutations was higher in colorectal than in gastric carcinomas (
P
=
0.016). In colorectal carcinoma,
PIK3CA mutations occur preferentially together with activating
KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas
PIK3CA mutations tend to occur as isolated events (MSI). |
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ISSN: | 0959-8049 1879-0852 |
DOI: | 10.1016/j.ejca.2005.04.022 |