Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release : evidence for specificity of impaired beta cell adaptation

• Published in: Diabetologia 2005-07, Vol.48 (7), p.1350-1358
• Main Authors: HULL, R. L, KODAMA, K, UTZSCHNEIDER, K. M, CARR, D. B, PRIGEON, R. L, KAHN, S. E
• Format: Article
• Language: English
• Subjects: Adaptation; Animals; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Body Weight - drug effects; Diabetes; Diabetes. Impaired glucose tolerance; Dietary Fats - pharmacology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose; Hyperplasia; Insulin - blood; Insulin - metabolism; Insulin resistance; Insulin Secretion; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Islets of Langerhans - pathology; Male; Medical sciences; Medicine; Metabolic diseases; Metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphology; Obesity; Oils & fats
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-005-1772-9

Increased dietary fat intake is associated with obesity and insulin resistance, but studies have shown that the subsequent increase in insulin release is not appropriate for this obesity-induced insulin resistance. We therefore sought to determine whether the impaired beta cell adaptation is due to inadequate expansion of the beta cell population or to a lack of an adaptive increase in insulin release. Male mice were fed diets containing increasing amounts of fat (15, 30 or 45% of energy intake) for 1 year, after which islet morphology and secretory function were assessed. Increased dietary fat intake was associated with a progressive increase in body weight (p