Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation

This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-transl...

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Bibliographic Details
Published in:Endocrine 2005, Vol.26 (3), p.249-257
Main Authors: Menon, K M J, Clouser, Christine L, Nair, Anil K
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation - physiology
Glycosylation
Humans
Palmitates - metabolism
Phosphorylation
Protein Processing, Post-Translational - physiology
Protein Transport
Receptors, FSH - biosynthesis
Receptors, FSH - metabolism
Receptors, LH - biosynthesis
Receptors, LH - metabolism
RNA, Messenger - metabolism
Transcription, Genetic - physiology
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Summary:This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-translationally and plays a role in the maturation and processing of the receptor, while palmitoylation is involved in receptor endocytosis and post-endocytic trafficking. A third type of post-translational modification is phosphorylation and its function has been reviewed. Finally, the regulation of LH receptor at the mRNA level by an RNA binding protein is discussed in the context of ovarian function.
ISSN:1355-008X
DOI:10.1385/endo:26:3:249