The Lectin Helix pomatia Agglutinin as a Marker of Metastases - Clinical and Experimental Studies

The prognosis for the majority of patients suffering from a solid neoplasm remains bleak, due to the fact that most cancers have already formed metastases at distant sites. Any progress in cancer therapy will, therefore, depend on the understanding of the metastatic cascade and therapies derived fro...

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Bibliographic Details
Published in:Anticancer research 2005-05, Vol.25 (3A), p.1829-1830
Main Authors: SCHUMACHER, Udo, BROOKS, Susan A, MESTER, Janos
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line, Tumor
Humans
Lectins
Medical sciences
Mice
Mice, SCID
Neoplasm Metastasis - diagnosis
Tumors
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Summary:The prognosis for the majority of patients suffering from a solid neoplasm remains bleak, due to the fact that most cancers have already formed metastases at distant sites. Any progress in cancer therapy will, therefore, depend on the understanding of the metastatic cascade and therapies derived from this understanding. The development of clinically relevant models of metastases, using lectin-defined human cancer cell lines and severe combined immunodeficient (SCID) mice, is described. In conjunction with modern imaging techniques, these models will help to elucidate the molecular mechanisms governing the metastatic spread of tumours.
ISSN:0250-7005
1791-7530