TPS, Thymidine Kinase, VEGF and Endostatin in Cytosol of Thyroid Tissue Samples

The aim of the study was to determine whether VEGF, TPS, TK or Endostatin determination in tissue cytosol may have some additional value in distinguishing among different types of thyroid lesions. These markers were chosen as representatives of the 2 main pathways (angiogenesis and proliferation) in...

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Bibliographic Details
Published in:Anticancer research 2005-05, Vol.25 (3A), p.1517-1521
Main Authors: PIKNER, R, LUDVIKOVA, M, RYSKA, A, KHOLOVA, I, HOLUBEC, L. JR, TOPOLCAN, O, PECEN, L, FINEK, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cytosol - metabolism
Endostatins - metabolism
Humans
Medical sciences
Thymidine Kinase - metabolism
Thyroid Diseases - metabolism
Thyroid Gland - metabolism
Tumors
Vascular Endothelial Growth Factor A - metabolism
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Summary:The aim of the study was to determine whether VEGF, TPS, TK or Endostatin determination in tissue cytosol may have some additional value in distinguishing among different types of thyroid lesions. These markers were chosen as representatives of the 2 main pathways (angiogenesis and proliferation) involved in thyroid diseases. VEGF is the most potent angiogenic promoter and Endostatin plays an opposing role. Thymidine kinase (TK) is a marker of DNA synthesis and TPS, cytokeratin 18 fragments, is a marker of the rate of proliferation. We determined qualitatively all four markers in tissue extracts: cytosol from 157 tissue specimens (93 goitre,12 Hashimoto's thyroiditis, 39 adenomas and 13 carcinomas). In 6 cases we were able to compare both normal and pathological tissue samples from a single patient. Statistically significant differences were found in the measured markers, but outliers were present in all groups. This fact does not permit their use in differential diagnosis. The highest levels of all markers were reached in adenomas, being higher than in carcinomas, probably explained by the higher overall metabolic rate in adenomas.
ISSN:0250-7005
1791-7530