Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue (MALT Lymphoma) in the Thymus: Report of Four Cases

Mucosa-associated lymphoid tissue (MALT) lymphoma in the thymus is extremely rare, and little is known about its clinicopathological features. In this study, we examined four cases of MALT lymphoma in the thymus at our institute in terms of clinicopathological features. Most patients had autoimmune...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 2005-07, Vol.35 (7), p.412-416
Main Authors: Shimizu, Kimihiro, Ishii, Genichiro, Nagai, Kanji, Yokose, Tomoyuki, Ishizawa, Kenichi, Tamaru, Junichi, Yoshida, Junji, Nishimura, Mituyo, Ochiai, Atushi
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Neoplasm - immunology
Autoantibodies - immunology
autoimmune disease
Female
Humans
hyperglobulinemia
Immunoenzyme Techniques
Lymphoma, B-Cell, Marginal Zone - immunology
Lymphoma, B-Cell, Marginal Zone - pathology
Male
MALT lymphoma
Middle Aged
thymus
Thymus Neoplasms - immunology
Thymus Neoplasms - pathology
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Summary:Mucosa-associated lymphoid tissue (MALT) lymphoma in the thymus is extremely rare, and little is known about its clinicopathological features. In this study, we examined four cases of MALT lymphoma in the thymus at our institute in terms of clinicopathological features. Most patients had autoimmune disease or hyperglobulinemia, and they also had cysts in the tumors. Both elevated serum levels of autoantibodies and the polyclonal increase in serum Ig remained almost unchanged after total thymectomy in all patients. We recommend that MALT lymphoma in the thymus should be considered in the differential diagnosis when a cystic thymic mass is found and if the patient is Asian and/or has autoimmune disease or hyperglobulinemia.
ISSN:0368-2811
1465-3621
DOI:10.1093/jjco/hyi105