Prognostic significance of pronormoblasts in erythrocyte predominant myelodysplastic patients

Recent studies of acute erythroleukemias have reaffirmed DiGuglielmo's syndrome (M6a, myeloblast‐predominant) and disease (M6b, pronormoblast‐predominant). M6c (mixed myeloblast/pronormoblast) has also been described. However, MDS is still defined according to the percentage of myeloblasts (% m...

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Bibliographic Details
Published in:American journal of hematology 2006-07, Vol.81 (7), p.484-491
Main Authors: Mazzella, Fermina M., Smith, David, Horn, Paul, Cotelingam, James D., Rector, James T., Shrit, M. Atef, Pesce, Amadeo, Schumacher, Harold R.
Format: Article
Language:English
Subjects:
Age Factors
Biological and medical sciences
blast
Disease-Free Survival
Erythroblasts - pathology
Erythrocyte Count
Erythrocytes - pathology
erythroid hyperplasia
erythroleukemia
Granulocyte Precursor Cells - pathology
Hematologic and hematopoietic diseases
Humans
Leukemia, Erythroblastic, Acute - mortality
Leukemia, Erythroblastic, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Models, Statistical
Multivariate Analysis
myelodysplastic syndrome
Myelodysplastic Syndromes - mortality
Myelodysplastic Syndromes - pathology
Platelet Count
Predictive Value of Tests
Prognosis
pronormoblast
Retrospective Studies
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Summary:Recent studies of acute erythroleukemias have reaffirmed DiGuglielmo's syndrome (M6a, myeloblast‐predominant) and disease (M6b, pronormoblast‐predominant). M6c (mixed myeloblast/pronormoblast) has also been described. However, MDS is still defined according to the percentage of myeloblasts (% myeloblasts) without including the pronormoblast count. A 20‐year retrospective study was performed to identify cases demonstrating ≥50% erythrocytic component and
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20563